[Science Update] Relationship between metabolites modulated by HMOs and reduced risk of LRTIs
In relation to the reduced incidence of lower respiratory tract infections (LRTIs) shown in infants fed a 2-HMO formula compared to those fed a control formula, the current study provided unique insights into how HMO feeding affects the developing gut microbiome-host metabolome in early infancy. In this study, the microbiota composition and biochemical species in infant stool (n = 743) from a previous clinical trial were measured.
[Science Update] Early-life gut ecology and reduced risk for reported LRTI
By using results from a clinical intervention trial with 2-human milk oligosaccharide (HMO) and control formula-fed infants, the current study sought to discover early-life infant parameters and microbiome characteristics linked to subsequently reported lower respiratory tract illnesses (LRTI) including bronchitis.
[Literature library] Effects of a specific blend of 5 HMOs on gut microbiota development and maturation
According to a multi-country trial, an infant formula containing a particular combination of 5 HMOs (2’-FL, DFL, LNT, 3’-SL and 6’-SL) has been shown to be able to beneficially modulate the gut maturation of formula-fed infants. The entire study consists of a follow-up period up to 15 months of age, with the present report analyzing the secondary outcomes for subjects up to 6 months of age only.
[Local Data] Caffeine intake and mineral metabolism among various maternal vitamin D statuses
A recently published local study is the first to demonstrate that health consequences of caffeine intake during pregnancy may differ across women based on their serum 25(OH)D concentrations. Peripheral blood samples from 181 randomly selected healthy pregnant women were collected. Information of their demographic and dietary intake were collected via questionnaires.
[Science Update] Recommendations for optimal prenatal supplementation for women in the US
In order to lower the risk of a variety of pregnancy and infant health issues, a study offers evidence-based recommendations for the optimal level of vitamins in prenatal supplements for women in the US. In total, 13 vitamins and 3 related nutrients have been reviewed. These recommendations are intended for the general population.
[Science Update] Neurodevelopmental outcomes in infants and maternal SARS-CoV-2 infections
The global spread of COVID-19 has affected pregnant women increasingly. To evaluate the neurodevelopmental outcomes of newborns delivered to mothers with SARS-CoV-2 infections during pregnancy, a prospective cohort study was conducted in Kuwait. The neurodevelopmental status of 298 infants at 10-12 months post-discharge was assessed by the Ages and Stages Questionnaire, 3rd edition (ASQ-3).
[Science Update] Maternal vitamin D supplementation during pregnancy and offspring’s risk of atopic eczema
A follow up of the Maternal Vitamin D Osteoporosis Study (MAVIDOS) is the first trial to demonstrate the relationship between prenatal cholecalciferol supplementation and risk of atopic eczema in offspring. In total 703 pairs of mother and offspring were included in the analysis.