Human Milk Oligosaccharides (HMO) | Wyeth Nutrition Science Center Hong Kong

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Potential Applications of Human Milk Oligosaccharides in Infant Formulas and Pharmacology

Human milk oligosaccharides (HMOs) have the potentials to impact infant health via numerous mechanisms.
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Review on the role of two human milk oligosaccharide, 2’-fucosyllactose and lacto-N-neotetraose, in infant nutrition

This review provided insight into human milk oligosaccharides (HMOs), the third abundant component of human milk. It summarized current evidence and concluded functions and health benefits of HMOs.
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Carbohydrates in human milk and body composition of infants during the first year of life

This study investigated relationships between the intake of human milk carbohydrates in the first year of life and infant body composition. Higher total carbohydrate concentrations, including human milk oligosaccharides (HMOs), were associated with increased lean mass and reduced adiposity.
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Bovine milk oligosaccharides (BMOs) influence growth-related characteristics of intestinal cells

This in vitro study found that specific BMOs could inhibit intestinal cell proliferation and have effects on gut differential processes, indicating BMOs may play a role in gastrointetinal development and maturation.
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Structures and metabolic properties of bovine milk oligosaccharides (BMOs)

This review detailed the potential metabolic effects of bovine milk oligosaccharides (BMOs) that may be structurally similar to human milk oligosaccharides (HMOs) and explored the possibility of their industrial production for therapeutic uses.
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Deciphering the antibacterial properties of human milk oligosaccharides (HMOs)

The authors have identified several HMOs with potent antimicrobial activity against the pathogen Group B Steptococcus, and uncovered the mechanism of action of HMO antimicrobial activity such as by increasing bacterial cell permeability.
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https://hongkong.wyethnutritionsc.org/human-milk-oligosaccharides-hmo/impact-human-milk-sialylated-structures-infant-protection

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The impact of human milk sialylated structures on infant protection, development and well-being

This review paper studied the significance of sialylated structures in human milk, such as the 3’-sialyllactose (3’-SL) type of human milk oligosaccharides (HMOs), and how they contribute to newborn protection and development.
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New horizons in supporting health outcomes

A symposium hosted by the Hong Kong Society of Paediatric Gastroenterology, Hepatology and Nutrition (HKSPGHAN), and supported by the Wyeth Nutrition Science Center (WNSC) Hong Kong.
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Human milk oligosaccharides (HMOs) and the prevention of necrotizing enterocolitis

This review paper takes reader through the almost 20-year long journey in the research of human milk oligosaccharides (HMOs) in the prevention of necrotizing enterocolitis (NEC), including recent human mother-infant cohort studies that confirmed specific HMOs are associated with lower NEC risk.
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Human milk oligosaccharides (HMOs) and microbiome modulate neonatal rotavirus infection

This study provided insights on the potential role of bioactive components in human milk such as human milk oligosaccharides (HMOs) and the microbiome in impacting the performance of live, attenuated rotavirus vaccines.