Pediatric Health & Nutrition
[Science Update] Relationship between metabolites modulated by HMOs and reduced risk of LRTIs
In relation to the reduced incidence of lower respiratory tract infections (LRTIs) shown in infants fed a 2-HMO formula compared to those fed a control formula, the current study provided unique insights into how HMO feeding affects the developing gut microbiome-host metabolome in early infancy. In this study, the microbiota composition and biochemical species in infant stool (n = 743) from a previous clinical trial were measured.
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https://hongkong.wyethnutritionsc.org/pediatric-health-nutrition/science-update-relationship-between-metabolites-modulated-hmos-and
[Science Update] Early-life gut ecology and reduced risk for reported LRTI
By using results from a clinical intervention trial with 2-human milk oligosaccharide (HMO) and control formula-fed infants, the current study sought to discover early-life infant parameters and microbiome characteristics linked to subsequently reported lower respiratory tract illnesses (LRTI) including bronchitis.
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https://hongkong.wyethnutritionsc.org/pediatric-health-nutrition/science-update-early-life-gut-ecology-and-reduced-risk-reported-lrti
[Literature library] Effects of a specific blend of 5 HMOs on gut microbiota development and maturation
According to a multi-country trial, an infant formula containing a particular combination of 5 HMOs (2’-FL, DFL, LNT, 3’-SL and 6’-SL) has been shown to be able to beneficially modulate the gut maturation of formula-fed infants. The entire study consists of a follow-up period up to 15 months of age, with the present report analyzing the secondary outcomes for subjects up to 6 months of age only.
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https://hongkong.wyethnutritionsc.org/pediatric-health-nutrition/literature-library-effects-specific-blend-5-hmos-gut-microbiota
[Science Update] Neurodevelopmental outcomes in infants and maternal SARS-CoV-2 infections
The global spread of COVID-19 has affected pregnant women increasingly. To evaluate the neurodevelopmental outcomes of newborns delivered to mothers with SARS-CoV-2 infections during pregnancy, a prospective cohort study was conducted in Kuwait. The neurodevelopmental status of 298 infants at 10-12 months post-discharge was assessed by the Ages and Stages Questionnaire, 3rd edition (ASQ-3).
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https://hongkong.wyethnutritionsc.org/brain-science/science-update-neurodevelopmental-outcomes-infants-and-maternal-sars-cov-2-infections
[Science Update] The impact of nutritional interventions on preschoolers' cognitive development
A recently published review article investigated the impacts of nutritional interventions on preschool children’s (aged 2 – 6 years) cognitive outcomes. In total, 12 Randomized Controlled Trials (RCTs) performed between 2000 and 2021 were included in the systemic review. Cognitive outcomes were assessed via various standardized cognitive tests*. The study showed that cognitive development of undernourished preschoolers can be positively impacted by nutritional interventions such as micronutrient supplementation. Besides, increasing fish consumption improves cognitive abilities of nourished children.
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https://hongkong.wyethnutritionsc.org/general-nutrition/science-update-impact-nutritional-interventions-preschoolers-cognitive
[Science Update] Maternal diet and HMO profile
In this study, the association between maternal nutrition and human milk oligosaccharide (HMO) profile in mature human milk was investigated. Human milk samples of healthy mothers (n = 101) from the Maternal Microbes (MAMI) cohort* was analyzed. Maternal dietary information and perinatal factors from the same group of subjects were recorded.
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https://hongkong.wyethnutritionsc.org/maternal-health-nutrition/science-update-maternal-diet-and-hmo-profile
[Guideline Summary] S3 guidelines on allergy prevention
Recommendations of the S3 guideline Allergy Prevention were revised to enable evidence-based and updated recommendations for preventing allergic diseases. They are for primary prevention of bronchial asthma, allergic rhinitis, food allergy and atopic eczema, applying to individuals at risk and those not at risk (unless explicitly stated otherwise. Below listed a brief summary.
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https://hongkong.wyethnutritionsc.org/allergies-immunity/guideline-summary-s3-guidelines-allergy-prevention