[Local Data] Serum vitamin D level and in vitro fertilization

Study background

• In total, 1,178 women undergoing the first IVF cycle between 2012 and 2016 were included
  • 1,113 had pregnancy outcome available from the completed IVF cycle
  • Median age (interquartile range): 36 (34 - 38) years old
• Serum samples were collected before ovarian stimulation for 25(OH)D level analysis
   

Key results

• Median serum 25(OH)D level: 53.4 (41.9 - 66.6) nmol/L
• Prevalence of vitamin D deficiency*: 42.2% (497 out of 1,178)
• Prevalence of vitamin D insufficiency and deficiency*: 86.7% (1,021 out of 1,178)
• Significantly lower levels of serum 25(OH)D were observed among women undergoing IVF in spring and winter, when compared to those in summer and autumn
• The vitamin D deficient group had significantly lower CLBR when compared to the non-deficient group^ (43.9%, 208/474 vs 50.9%, 325/639, OR 0.755, 95% CI 0.595 – 0.959, P = 0.021, unadjusted)
• The vitamin D replete group had higher CLBR when compared to the vitamin D insufficient group, which had higher CLBR than that of the vitamin D-deficient group (51.7% (74/143), 50.6% (251/496) and 43.9% (208/474), P = 0.031)
• The vitamin D deficient group used a higher total dosage of gonadotropins compared to the non-deficient group
• Longer stimulation duration, less oocytes retrieved and less normally fertilized oocytes were observed in the vitamin D deficient group when compared to the non-deficient group
   

*Serum 25(OH)D level < 50 nmol/L was considered as vitamin D deficiency; 50 nmol/L < serum 25(OH)D level < 75 nmol/L was considered as vitamin D insufficiency; serum 25(OH)D level > 75 nmol/L was considered as replete
^Vitamin D non-deficient group refers to vitamin D insufficient and replete groups

Link to the full article:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859949/pdf/EC-21-0444.pdf
 

Reference:

Ko JKY et al. 100 Years of vitamin D: Effect of serum vitamin D level before ovarian stimulation on the cumulative live birth rate of women undergoing in vitro fertilization: a retrospective analysis. Endocr Connect. 2022;11(2):e210444.
 

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WYE-EM-059-MAY-22