Results showed that:
- 24 mothers (11.4%) and 17 infants (8.2%) were identified as non-secretors i.e. FUT2-negative
- 13 mothers (6.2%) and 8 infants (3.8%) were identified as Lewis-negative i.e. FUT3-negative
- Infants of secretor-positive mothers had a lower incidence of ARIs during the first 6 months of life*, with an incidence rate ratio of 0.66 (95% confidence interval. 0.47 to 0.94; p = 0.020)
- Maternal Lewis status was not linked to ARI occurrence during the first 6 months of life
- Maternal secretor and Lewis status showed no significant association with ARI occurrence in infants during later time points
- Maternal secretor and Lewis status showed no significant association with nasopharyngeal microbiome composition
Conclusion
This study further supported that fucosylated HMOs were associated with lower risk of respiratory infections in exclusively or predominantly breastfed infants.
*Compared to that of infants of non-secretor mothers
Link to the abstract:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579893/pdf/msphere.00686-21.pdf
Reference:
Binia A et al. The Influence of FUT2 and FUT3 polymorphisms and nasopharyngeal microbiome on respiratory infections in breastfed Bangladeshi infants from the Microbiota and Health Study. mSphere. 2021;6(6):e0068621.
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