[Literature Library] Human milk oligosaccharide 3’-sialyllactose (3’-SL) and language development during infancy

The presence of human milk oligosaccharide (HMO) A-tetra in human milk is subject to the genetic profile of the mother, with presence associated with maternal blood type A. In this study, human milk samples were collected from 99 mother-child dyads and stratified into those with or without A-tetra HMO (A-tetra+ or A-tetra-). Significant associations were found in the A-tetra+ group, where higher 3’-SL concentration in human milk was associated with a higher early learning composite score in children, mainly attributed by receptive and expressive language scores.