The influence of lifestyle before conception on pregnancy loss

Thursday, Feb 01, 2018

Latest: The influence of lifestyle before conception on pregnancy loss


Buck Louis GM, Sapra KJ, Schisterman EF, Lynch CD, Maisog JM, Grantz KL, Sundaram R. Lifestyle and pregnancy loss in a contemporary cohort of women recruited before conception: The LIFE Study. Fertil Steril. 2016 Mar 22. [Epub ahead of print]. Link to Pubmed


  • Most traditional research focuses exclusively on female determinants that interfere with pregnancy loss
  • Objective: To estimate the incidence of pregnancy loss and associated lifestyle risk factors in a couple-based prospective cohort that was enrolled prior to conception and followed throughout preconception and pregnancy


  • 344 couples from 16 counties in Michigan and Texas with a singleton pregnancy were followed through 7 postconception weeks of gestation
  • Daily use of cigarettes, caffeinated and alcoholic beverages and multivitamin were recorded in 3 sensitive windows of reproduction
    • Preconception window: The time from enrollment to estimated conception
    • Early pregnancy window: The day after conception (or peak luteinizing hormone) through 7 postconception weeks
    • Periconception window: An overall window including the above windows
  • Incidence and risk factors for pregnancy loss were measured

Key Findings:

  • 28% pregnant women (98 out of 344) experienced an observed pregnancy loss
  • Women’s caffeine consumption (>2 cups of caffeinated drinks+ daily) was significantly associated with pregnancy loss
    • Preconception: Adjusted HR = 1.74, 1.07-2.81
    • Early pregnancy: Adjusted HR = 3.05, 1.75-5.34
    • Periconception: Adjusted HR = 2.58, 1.56-4.27
  • Men’s caffeine consumption (>2 cups of caffeinated drinks+ daily) was also significantly associated with pregnancy loss
    • Preconception: Adjusted HR = 1.73, 1.10-2.72
    • Early pregnancy: Adjusted HR = 1.88, 1.21-2.93
    • Periconception: Adjusted HR = 1.75, 1.12-2.74

+ A caffeinated drink was defined as a cup of coffee or tea or a can of soda (excluding decaffeinated or caffeine-free beverages)

  • Women’s vitamin adherence was associated with a reduced risk of pregnancy loss in different windows
    • Preconception: Adjusted HR = 0.45, 0.25-0.80
    • Early pregnancy: Adjusted HR = 0.21, 0.10-0.43
    • Periconception: Adjusted HR = 0.22, 0.11-0.44
  • No significantly association between other lifestyle characteristics and pregnancy loss was noted in any of the final adjusted models


  • Couples’ lifestyles in the preconception period were related to the risk of pregnancy loss, but women’s multivitamin adherence substantially reduced the risk



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