The effect of multi mineral-vitamin D supplementation on pregnancy outcomes in pregnant women at risk for pre-eclampsia

Thursday, Feb 01, 2018

Latest: A study on the effects of calcium, magnesium, zinc and vitamin D supplementation in pregnant women at risk for pre-eclampsia

Reference

Asemi Z and Esmaillzadeh A. The effect of multi mineral-vitamin D supplementation on pregnancy outcomes in pregnant women at risk for pre-eclampsia. Int J Prev Med. 2015;6:62. Link to PubMed

  • Background:
    • Maternal micronutrient supplementation is among the various strategies that help reduce complications in pregnant women at risk for pre-eclampsia. Important nutrients and possible mechanisms include:
      • Calcium and magnesium reduce parathyroid calcium release and regulate intracellular calcium concentrations, in addition to increasing the sensitivity of vascular smooth muscle to nitric oxide
      • Zinc and Vitamin D influence the regulation of insulin-like growth factor I and its receptor, to attain improved insulin sensitivity and gene expression associated with normal implantation and angiogenesis
    • Objective
      • To investigate the effect of multi mineral-vitamin D supplementation on pregnancy outcomes in pregnant women at risk for pre-eclampsia
         
  • Method:
    • Subjects
      • A total of 46 pregnant women aged 18 – 40 years old completed the trial
      • Carrying singleton pregnancy at their third trimester and at risk for pre-eclampsia as indicated by a positive roll-over test
      • Randomly assigned to receive either the placebo (n = 23) or multi mineral-vitamin D supplements (n = 23) over 9 weeks
    • The multi mineral-vitamin D supplements given contained 800 mg calcium, 200 mg magnesium, 8 mg zinc and 400 IU vitamin D3
    • Key outcomes assessed include:
      • Pregnant women: body mass index (BMI), blood pressure, serum calcium, magnesium, zinc, iron and 25-hydroxy vitamin D levels
      • Newborns: length, weight, head circumference
       
  • Key Findings:
    • In comparison to placebo, multi mineral-vitamin D supplementation resulted in:
      • Decreased maternal blood pressure for systolic (-1.08 mmHg vs. 6.08 mmHg, p = 0.001) and diastolic pressure (-0.44 mmHg vs. 3.05 mmHg, p = 0.02)
      • Increased maternal serum levels of
        • Calcium (+0.19 mg/dL vs. -0.08 mg/dL, p = 0.03)
        • Magnesium (+0.15 mg/dL vs. -0.08 mg/dL, p = 0.03)
        • Zinc (+8.25 mg/dL vs. -21.38 mg/dL, p = 0.001)
        • Vitamin D (+3.79 ng/ml vs. -1.37 ng/ml, p = 0.01)
      • Increased newborns’ length (51.3 cm ± 1.7 cm vs. 50.3 cm ± 1.2 cm, p = 0.03)
      • No significant differences in newborns’ weight and head circumference, or maternal serum iron levels
         
  • Conclusion:
    • Multi mineral-vitamin D supplementation for 9 weeks in pregnant women at risk for pre-eclampsia resulted in positive maternal and fetal outcomes

 

WYE-EM-288-OCT-15


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