Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial

Thursday, Feb 01, 2018

Latest: Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial


Weber M, Grote V, Closa-Monasterolo R, Escribano J, Langhendries J, Dain E, Giovannini M, Verduci E, Gruszfeld D, Socha P, Koletzko B for The European Childhood Obesity Trial Study Group.  Am J Clin Nutr. 2014 May; 99(5):1041-51. doi: 10.3945/ajcn.113.064071. Epub 2014 Mar 12. Link to Pubmed  

  • Background:
    Nutrition in early life has been recognized as an effective target for preventing childhood obesity. Data from Childhood Obesity Project (CHOP) has shown that infants received infant formula that contained higher amount of protein – 2.05 g/dL (HP) had more weight gain during the first year of life and were heavier at age of 2 than those received lower protein diet – 1.25 g/dL (LP). The current study is the follow up cohort at 6 years of age.
  • Method:
    • Multicenter, double-blind, randomized control trial
    • 1090 healthy infants were randomized into HP and LP groups in the first year of life; breast-fed infants (n = 588) were enrolled as reference group
    • Weight and height were measured at 6 years of age for calculation of BMI
  • Key Findings:
    • Children, at the age of 6, in the HP group had a significantly higher BMI (by 0.51; 95% CI: 0.13, 0.90;
      P = 0.009) than those in the LP group
    • The risk of becoming obese was 2.43 times (95% CI: 1.12, 5.27; P = 0.024) in HP group when compared with LP group
    • There was a tendency of higher weight observed in the HP group (0.67kg; 95% CI: -0.04, 1.39; P = 0.064) but no difference in height between HP and LP groups
  • Conclusion:
    • Optimal infant nutrition is important as it lays the foundation for future health
    • Protein intake during infancy may influence risk of obesity at 6 years of age



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