Maternal iodine status and its impact on offspring language skills

Monday, Jan 21, 2019

Iodine inadequacy can affect the production of thyroid hormones, leading to impaired brain development in fetal life.

Reference:

Markhus MW, Dahl L, Moe V, Abel MH, Brantsæter AL, Øyen J, Meltzer HM, Stormark KM, Graff IE, Smith L, Kjellevold M. Maternal iodine status is associated with offspring language skills in infancy and toddlerhood. Nutrients. 2018;10(9). pii: E1270.
Link to the full article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163597/
 

Other online article that you might be interested in:

Interview with Prof. Tam Wing Hung – Be alert: Nutritional status during pregnancy

Background

  • Iodine deficiency is a common nutritional disorder over the globe and is a key cause of preventable brain impairment
  • This study aimed to reveal,
    • Association between maternal iodine status during pregnancy and child neurodevelopment at 6, 12 and 18 months of life

Study Design

  • A population-based prospective cohort in Norway

Subjects

  • This study included 851 mother-child dyads with singleton pregnancies
     

Method

  • A spot urine sample was collected for determination of urine iodine concentration (UIC)
  • Child neurodevelopment was assessed at 6, 12 and 18 months via meeting with a research assistant
     

Key Findings

  • The median UIC in pregnancy was 78 mcg/L
    • 79% (676 out of 851) women showed a UIC < 150 mcg/L
    • 28% (242 out of 851) women showed a UIC < 50 mcg/L
  • 18% (155 out of 851) women reported use of an iodine-containing supplement during the last 3 months before the collection of urine sample
    • Higher UIC was noted in supplement users (median 92 mcg/L) versus non-supplement users (median 77 mcg/L) (p < 0.001)
  • A low UIC mcg/L during pregnancy (< ~100 mcg/L) was,
    • Significantly related to poorer skills in language domains (receptive and expressive) in infancy and toddlerhood
    • NOT related to poorer cognitive score or fine- and gross mother skills
  • Use of iodine-containing supplement during pregnancy was related to poorer gross motor skills (standard beta = -0.18, 95% CI = -0.33, -0.33, p = 0.02)
     

Conclusion

  • Insufficient iodine intake during pregnancy was linked to lower infant language skills up to 18 months

Maternal iodine status and its impact on offspring language skills

Monday, Jan 21, 2019

Iodine inadequacy can affect the production of thyroid hormones, leading to impaired brain development in fetal life.

Reference:

Markhus MW, Dahl L, Moe V, Abel MH, Brantsæter AL, Øyen J, Meltzer HM, Stormark KM, Graff IE, Smith L, Kjellevold M. Maternal iodine status is associated with offspring language skills in infancy and toddlerhood. Nutrients. 2018;10(9). pii: E1270.
Link to the full article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163597/
 

Other online article that you might be interested in:

Interview with Prof. Tam Wing Hung – Be alert: Nutritional status during pregnancy

Background

  • Iodine deficiency is a common nutritional disorder over the globe and is a key cause of preventable brain impairment
  • This study aimed to reveal,
    • Association between maternal iodine status during pregnancy and child neurodevelopment at 6, 12 and 18 months of life

Study Design

  • A population-based prospective cohort in Norway

Subjects

  • This study included 851 mother-child dyads with singleton pregnancies
     

Method

  • A spot urine sample was collected for determination of urine iodine concentration (UIC)
  • Child neurodevelopment was assessed at 6, 12 and 18 months via meeting with a research assistant
     

Key Findings

  • The median UIC in pregnancy was 78 mcg/L
    • 79% (676 out of 851) women showed a UIC < 150 mcg/L
    • 28% (242 out of 851) women showed a UIC < 50 mcg/L
  • 18% (155 out of 851) women reported use of an iodine-containing supplement during the last 3 months before the collection of urine sample
    • Higher UIC was noted in supplement users (median 92 mcg/L) versus non-supplement users (median 77 mcg/L) (p < 0.001)
  • A low UIC mcg/L during pregnancy (< ~100 mcg/L) was,
    • Significantly related to poorer skills in language domains (receptive and expressive) in infancy and toddlerhood
    • NOT related to poorer cognitive score or fine- and gross mother skills
  • Use of iodine-containing supplement during pregnancy was related to poorer gross motor skills (standard beta = -0.18, 95% CI = -0.33, -0.33, p = 0.02)
     

Conclusion

  • Insufficient iodine intake during pregnancy was linked to lower infant language skills up to 18 months


Hot Science

Creation Date: Monday, Jan 07, 2019

  • Maternal iodine status and its impact on offspring language skills
opened book

Want to read the full article?

This content is for registered users only. Registration is free for healthcare professionals.


WYE-EM-435-DEC-18

Latest Articles

Academic Activities

Scientific symposium – Critical connectivity: Assessing and supporting the development of brain and behaviour

Chairperson:

  • Dr Henry Au Yeung Cheuk-lun (Hong Kong)
Speakers:
  • Professor Weili Lin (USA)
  • Dr Daniel Chiu Cheung-shing (Hong Kong)
  • Dr Fanny Lam Wai-fan (Hong Kong)

The 28th International Congress of Pediatrics (IPA) (NEW!)

17-22 August 2016, Vancouver, Canada

Science Updates

Infants are exposed to human milk oligosaccharides (HMOs) already in utero (NEW!)

This is the first study to find that human milk oligosaccharides (HMOs) is present in amniotic fluid and that the fetus is exposed to HMOs in utero already.

Infant feeding tolerance on formula supplemented with sn-2 palmitate and oligofructose

This study explored the stool characteristics and feeding tolerances of infants fed formulas supplemented with sn-2 palmitate and oligofructose, both exclusively and when mixed-fed with human milk.

Resources

Picky Eating eBook

Practical tips to overcome picky eating behaviours by Kate Di Prima, an accredited practicing dietitian specializing in Paediatrics and a spokesperson for the Dietitians Association of Australia. 

Growth Charts

The WHO Child Growth Standards were developed using data collected in the WHO Multicentre Growth Reference Study (MGRS)1.