Impact of prenatal multiple micronutrient supplement on survival and growth during infancy

Thursday, Feb 01, 2018


Roberfroid D, Huybregts L, Lanou H, Ouedraogo L, Henry MC, Meda N, Kolsteren P. Impact of prenatal multiple micronutrients on survival and growth during infancy: a randomized controlled trial. Am J Clin
Nutr. 2012 Apr;95(4):916-924. Epub 2012 Feb 29.
Link to PubMed

  • Background:
    Multiple micronutrient deficiencies might contribute to low birth weight. UNICEF/WHO/United Nations University have formulated a multiple micronutrient supplement (UNIMMAP) for pregnant and lactating women.
    • UNIMMAP contains one recommended daily allowance (RDA) of 15 micronutrients.
  • Method:
    1294 US pregnant women were randomly assigned to take either UNIMMAP or iron and folic acid supplement (IFA).
    • The growth of infants was assessed monthly up to 12 months and at 30 months.
  • Key findings:
    Compared to the IFA group, the UNIMMAP resulted in infants with:
    • A 27% reduction in the rate of stunting over the first 12 months
    • A significant higher length-for-age z score of 0.13 over the first 12 months.
    • A trend towards a higher weight-for-length and head circumference-for-age by the end of 12 months.
    • A higher weight-for-height z score of 0.20 by the age of 30 months.
    • A 14% reduction in reported episodes of fever.
    • No difference in mortality or morbidity.
  • Conclusion:
    UNIMMAP supplementation in pregnant mothers improved fetal growth with continuation into early life.


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