Choline metabolites status and neurodevelopmental outcomes in children

Thursday, Feb 01, 2018


Strain JJ, McSorley EM, van Wijngaarden E, Kobrosly RW, Bonham MP, Mulhern MS,McAfee AJ, Davidson PW, Shamlaye CF, Henderson J, Watson GE, Thurston SW, WallaceJM, Ueland PM, Myers GJ. Choline status and neurodevelopmental outcomes at 5years of age in the Seychelles Child Development Nutrition Study.Br J Nutr. 2013 Jul;110(2):330-6. doi: 10.1017/S0007114512005077. Link to PubMed

  • Background:
    Choline is an essential nutrient which plays key roles in the development of central nervous system, where animal studies have shown choline status during developmental period is associated with cognitive outcomes.
  • Method:
    • 210 children were recruited from an ongoing maternal study in the Republic of Seychelles at age 5 years.
    • Venous non-fasting blood samples were collected for measuring the plasma concentrations of free choline and its metabolites.
    • Specific measures conducted with the neurodevelopmental test battery, which included anthropometry and a series of cognitive, motor and language tests.
  • Key findings:
    • Mean concentration of plasma free choline – 9.17 µmol/L.
    • Plasma free choline concentration was significantly correlated with concentrations of betaine (p = 0.0006), dimethylglycine (p = 0.03), methionine (p = 0.0005) and homocysteine (p = 0.006) concentrations.
    • Plasma betaine concentrations was positively associated with Preschool Language Scale – total language scores (p = 0.04).
    • Associations with other biomarkers were not evident.
  • Conclusion:
    Associations between choline concentrations and neurodevelopmental outcomes in children warrant further study.



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